Background:

MCTS1 (malignant T cell amplified sequence 1), also known as MCT1, is a 181 amino acid protein that is ubiquitously expressed and localizes to the cytoplasm of cells. MCTS1 may play a role in cell cycle regulation by decreasing cell doubling time and by shortening the duration of G1 transit time and G1/S transition. The protein level of Cdk4 and Cdk6 kinases activity and cyclin D1 is enhanced by expression of MCTS1. As a translation enhancer, MCTS1 recruits DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile. MCTS1 promotes lymphoid tumor development and contributes to the pathogenesis and progression of breast cancer. MCTS1 positively regulates phosphorylation of ERK1 and ERK2.

Applications:

ELISA, WB, IHC

Name of antibody:

MCTS1

Immunogen:

Fusion protein of human MCTS1

Full name:

malignant T cell amplified sequence 1

Synonyms：

MCT1; MCT-1

SwissProt:

Q9ULC4

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human colon cancer and human esophagus cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

21 kDa

WB Positive control:

Jurkat and K562 cells, PC3 and A549 cells

WB Recommended dilution:

200-1000