Full name:

optineurin

Synonyms:

NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP

Swissprot:

Q96CV9

Gene Accession:

BC013876

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and *****-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.